Dallas Cowboys at San Francisco 49ers: Predictions, picks and odds for NFL Week 5 game

One of the juiciest matchups of the NFL season is here, as the Dallas Cowboys (3-1) will travel to California to take on the San Francisco 49ers (4-0) on "Sunday Night Football."

After the confusing loss to the Arizona Cardinals, the Cowboys righted the ship with a complete performance against the New England Patriots. The offense was clicking, and the defense was back to making life a nightmare for the offense with two touchdowns. The 35-point blowout was the biggest loss of Bill Belichick's career.

One of two undefeated teams left, San Francisco flexed its muscle once again in a win against the Cardinals team that just beat Dallas. Christian McCaffrey has emerged as an early MVP favorite, and his four-touchdown day provided momentum for the offense. In a rematch of a playoff matchup, who will emerge as thre true NFC leader?

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Dallas Cowboys defensive end DeMarcus Lawrence (90) tackles San Francisco 49ers wide receiver Deebo Samuel (19) during the first quarter of a NFC divisional round game at Levi's Stadium.
Dallas Cowboys defensive end DeMarcus Lawrence (90) tackles San Francisco 49ers wide receiver Deebo Samuel (19) during the first quarter of a NFC divisional round game at Levi's Stadium.

49ers vs. Cowboys odds, moneyline, over/under

The 49ers are favorites to defeat the Cowboys, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: 49ers (-3.5)

  • Moneyline: 49ers (-185); Cowboys (+150)

  • Over/under: 45

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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NFL Week 5 odds, predictions and picks

Commanders vs. Bears | Bills vs. Jaguars | Falcons vs. Texans | Lions vs. Panthers | Colts vs. Titans | Dolphins vs. Giants | Patriots vs. Saints | Steelers vs. Ravens | Cardinals vs. Bengals | Rams vs. Eagles | Broncos vs. Jets | Vikings vs. Chiefs | 49ers vs. Cowboys | Raiders vs. Packers

Lorenzo Reyes: 49ers 31, Cowboys 25

As much as Dallas has said it remembers the last two times it has faced the Niners, San Francisco is the more balanced and explosive team. Christian McCaffrey’s speed is untouchable and the Cowboys struggled against the rush. Red zone inefficiency is one thing against weaker opponents; the Cowboys can’t leave points on the field against the 49ers.

Tyler Dragon: 49ers 27, Cowboys 20

This is easily the game of Week 5. The 49ers sent the Cowboys home in the playoffs in each of the past two seasons. San Francisco’s won 14 consecutive regular-season games. The streak won’t end this week. The 49ers are playing like the best team in football.

Victoria Hernandez: 49ers 27, Cowboys 25

A preview of the NFC championship perhaps? This game is in primetime for a reason. The Dallas defense will pose the toughest challenge yet for the undefeated 49ers. But Christian McCaffrey is on the brink of setting records this season and will power his team to victory.

Jordan Mendoza: 49ers 27, Cowboys 24

Both teams have elite offenses and defenses, so seeing who can win the battle between the two makes this game must-see TV. It'll be a close game, and I think the offenses will actually expose the defenses a bit, but the 49ers haven't shown any cause for concern this season. San Francisco is rolling, and they get a big win at home to cement themselves as the best team in the NFL.

You can view the full list of USA TODAY's NFL expert predictions here.

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This article originally appeared on USA TODAY: Dallas Cowboys at San Francisco 49ers: Game predictions, picks, odds