The Saints return home after being battered 24-15 by the Atlanta Falcons. Derek Carr threw for 300 yards for the fifth game this season, but failed to score a touchdown for the second straight matchup. Tyrann Mathieu had two interceptions.
The Lions had a few extra days to rebound from a 29-22 Thanksgiving loss to the Green Bay Packers. Jared Goff lost three fumbles. David Montgomery and Jahmyr Gibbs combined for 125 rushing yards and Montgomery had a rushing score.
Will Detroit be the dominant team they've shown in other games? Or will the Saints snag the home win?
Saints vs. Lions odds, moneyline, over/under
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Spread: Lions (-4)
Moneyline: Lions (-200); Saints (+165)
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NFL Week 13 odds, predictions and picks
Cowboys vs. Seahawks | Patriots vs. Chargers | Saints vs. Lions | Jets vs. Falcons | Steelers vs. Cardinals | Titans vs. Colts | Commanders vs. Dolphins | Texans vs. Broncos | Buccaneers vs. Panthers | Eagles vs. 49ers | Rams vs. Browns | Packers vs. Chiefs | Jaguars vs. Bengals
Lorenzo Reyes: Lions 31, Saints 20
I think this is a great buy-low spot for the Lions. They have turned the ball over too much the last two weeks and know their offensive operation needs to be far cleaner. The Saints are 2-8-1 against the spread this season, 0-4 against the spread at home and have injury questions at receiver with Chris Olave (concussion) and Rashid Shaheed (quad) sustaining injuries in Week 12 against the Falcons.
Tyler Dragon: Lions 28, Saints 21
The Lions were stunned on Thanksgiving by the Packers. Maybe they were reading their own press clippings after winning three in a row. Detroit bounces back in New Orleans this week against a Saints squad that struggles with consistency.
Safid Deen: Lions 27, Saints 20
The Lions bounce back after their Thanksgiving loss to the Packers, while the Saints need to make a quarterback change if they’re gonna salvage their season.
Victoria Hernandez: Lions 27, Saints 20
The Lions will have had a few days to recover from their gnarly Thanksgiving beatdown. They face an uphill battle in a loud dome on the road, but Jared Goff should be able to protect the ball better and his duo of running backs are solid.
Jordan Mendoza: Lions 27, Saints 22
The Lions have shown cracks in recent weeks that should question how legit the defense is. A true test comes against a New Orleans offense trying to break through and stay in the playoff picture. However, Detroit’s offense is too good to drop another game.
You can view the full list of USA TODAY's NFL expert predictions here.
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This article originally appeared on USA TODAY: Detroit Lions at New Orleans Saints: Game predictions, picks, odds