Blues manager Mauricio Pochettino will sit in the away dugout for the first time as a manager in N17 as he looks to reverse his side's form in the most unwelcome of surroundings.
Pochettino oversaw Spurs' best period in decades during over five years in charge - culminating in a Champions League final - but returns as an enemy.
Ange Postecoglou, meanwhile, has taken his new squad to the top of the Premier League thanks to the best ever start to a season made by a newly-appointed manager. He will know another victory under the lights will be the most important of the lot, by a distance.
Date, kick-off time and venue
Tottenham vs Chelsea is scheduled for an 8pm GMT kick-off tonight on Monday November 6, 2023.
The match will take place at the Tottenham Hotspur Stadium in north London.
Where to watch Tottenham vs Chelsea
TV channel: In the UK, tonight's game will be televised live on Sky Sports, with Monday Night Football coverage beginning at 6.30pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action via Standard Sport’s live blog, with expert analysis from both Dan Kilpatrick and Nizaar Kinsella at the ground.
Tottenham vs Chelsea lineups and team news
Tottenham XI: Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Bissouma; Kulusevski, Johnson, Maddison; Son
Subs: Forster, Royal, Dier, Hojbjerg, Skipp, Bentancur, Lo Celso, Richarlison, Gil
Chelsea XI: Sanchez; James, Disasi, Silva, Colwill; Caicedo, Fernandez; Palmer, Gallagher, Sterling; Jackson.
Subs: Cucurella, Badiashile, Mudryk, Madueke, Ugochukwu, Gusto, Petrovic, Maatsen, Washington.
Tottenham vs Chelsea prediction
Spurs are clearly the team in form, they are top of the table after all, while Chelsea have just three league wins all season and come into the game after yet another unconvincing display, albeit in victory, against Championship Blackburn in the Carabao Cup.
But, as the saying goes, the form book can go out the window in derbies. This one in particular - given the intense rivalry and Pochettino's return - will require the calmest of heads to come out victors. Chelsea could cause an upset but Postecoglou will have his players ready not to let the occasion get to them.
Tottenham to win, 2-1.
Head to head (h2h) history and results
Tottenham wins: 56
Chelsea wins: 77
Spurs have won just one of the last nine Premier League derbies between these two teams after winning three of the previous four.
Tottenham vs Chelsea match odds
Tottenham to win: 13/10
Chelsea to win: 2/1
Odds via Betfair (subject to change).