Best CBD Gummies for Anxiety: Top Picks for Stress Relief

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It doesn’t seem to matter how hard you try, you always freeze up in certain situations. Whether it’s speaking to a group of people, performing well at your job or studies, or even going out in public, anxiety can get in the way of doing the things you need and love.

Thankfully, CBD gummies can be a convenient, effective way to relieve anxiety. With minimal side effects and a broad range of benefits, they can easily fit into your everyday life.

We’ve looked at the best CBD gummies for anxiety and found a few favorites. The best overall is FOCL Feel Good’s CBD + THC Gummies.

Top CBD Gummies for Anxiety: First Look

The best CBD gummies for sex contain an effective dose of CBD with natural hemp terpenes and other cannabinoids to complement its benefits.

Our top pick overall is FOCL Feel Good’s CBD + THC Gummies, with Cheech & Chong’s Cruise Chews coming in second.

FOCL Feel Good CBD + THC Gummies - Best CBD Gummies for Anxiety Overall

Pros

  • Tyrosine may boost motivation

  • Contains 25mg of CBD and 5mg of THC

  • Delicious blood orange flavor

Cons

  • THC may be illegal or inadvisable for your personal situation

Who is FOCL Feel Good CBD + THC Gummies Best For?

FOCL Feel Good CBD + THC Gummies are our favorite overall. They’re best for people who want full-spectrum CBD gummies for stronger anxiety relief.

Who Should Avoid FOCL Feel Good CBD + THC Gummies?

Avoid these gummies if you cannot take any amount of THC, such as if you must undergo drug testing.

FOCL Feel Good CBD + THC Gummies Ranking - 4.9/5

Effectiveness - 4.9/5

Although single-dose studies use higher amounts, the 25mg dose of CBD in FOCL Feel Good gummies may be effective with long-term use. A case series showed that this dose was enough to significantly relieve anxiety symptoms, with average scores falling from 23.87 to 16.36 within two to three months [1].

The addition of tyrosine may help if your anxiety is related to a heavy study or workload. Tyrosine supplementation can restore performance in cognitively intense or stressful situations, which could make exams, assessments, or demanding jobs easier [2].

Flavor - 4.9/5

With a delicious natural blood orange flavor, these CBD gummies taste like any other candy.

Customer Reviews - 4.9/5

FOCL Feel Good Gummies have many positive reviews on their benefits for stress relief, including: “They bring my stress level down and am able to handle whatever life throws at me!”

Price - 4.9/5

A subscription can save you 20%, at $55.20 for a month’s supply of 30 gummies. For a one-time purchase, each jar costs $69.00.

Summary

FOCL Feel Good gummies may directly relieve anxiety and provide support during situations that trigger it, such as exam periods or demanding jobs.

>>Check the best prices for FOCL Feel Good’s CBD + THC Gummies here

Cheech & Chongs Cruise Chews - All-Natural Full-Spectrum Gummies

Pros

  • Higher CBD dosage and lower dose of THC

  • Designed to have relaxing effects

  • Lifetime money-back guarantee

  • No artificial ingredients

Cons

  • Any amount of THC can still trigger a positive drug test

Who is Cheech & Chong’s Cruise Chews Best For?

If you have a full-spectrum CBD gummy free of artificial ingredients in mind, Cruise Chews are for you. We especially recommend them if your anxiety benefits from THC.

Who Should Avoid Cheech & Chong’s Cruise Chews?

Avoid Cruise Chews if you cannot have any amount of THC for legal or medical reasons.

Cheech & Chong’s Cruise Chews Ranking - 4.9/5

Effectiveness - 4.9/5

The higher dose of 30mg of CBD and lower THC dose, at 3mg, may be more effective for you thanks to the “entourage effect”. A lab study demonstrated that THC can improve the absorption of CBD by 12-21%. Female rats had a greater increase in CBD levels, so women may benefit more [3].

Some people in the case series on anxiety and insomnia needed 50 or even 75mg of CBD, so Cruise Chews may be better if you need a higher dose.

Flavor - 4.8/5

Cruise Chews come in a mix of fruit flavors, but these aren’t specified.

Customer Reviews - 4.9/5

Customer reviews from verified buyers include “I did sleep well and often and the pain I’ve had since my surgery didn’t bother me as much while sleep,” and “Cruise chews are awesome, just a slight mellow feel and they taste great. Recommend starting with a half and progress from there. You won’t be disappointed.”

Price - 4.9/5

The best value deal is the six-month package, costing you $39.95 per month. A one-time purchase costs you $59.00 and includes free shipping.

Summary

Cheech & Chong’s Cruise Chews are all-natural, full-spectrum CBD gummies with a stronger amount of CBD and a focus on the entourage effect.

>>Check the best prices for Cheech & Chong’s Cruise Chews here

FAB CBD PM Chews - Best CBD Gummies for Nighttime Anxiety

Pros

  • Added L-theanine, 5-HTP, melatonin, and GABA

  • Ashwagandha may reduce stress hormones

  • Subscribe and save 20%

  • Organic, non-GMO ingredients

Cons

  • It contains a lower dose of CBD at 12.5mg

Who is FAB CBD PM Chews Best For?

PM Chews are best for people whose anxiety disorders are worse at night or prevent them from sleeping well.

Who Should Avoid FAB CBD PM Chews?

FAB CBD’s PM Chews may not be suitable if your anxiety symptoms are least severe at night or if you already sleep well. Additionally, 5-HTP may have a harmful additive effect with antidepressants.

FAB CBD PM Chews Ranking - 4.8/5

Effectiveness - 4.9/5

PM Chews may have strong anxiolytic effects thanks to their combination of CBD, ashwagandha, L-theanine, and GABA.

For example, ashwagandha shows significant benefits in relieving anxiety and stress. It works by reducing stress hormones (which impact sleep) and increasing GABA and serotonin, benefits that PM Chews maximize with added GABA and 5-HTP [4].

Flavor - 4.8/5

PM Chews come in a sweet acai flavor with no artificial ingredients.

Customer Reviews - 4.9/5

Comments from verified buyers include “They are very helpful letting me fall asleep quicker and remaining asleep,” and “Love them! Work great & allow me a full 8 hours of zzzz’s!”

Price - 4.8/5

PM Chews cost $89.00 for a bottle of 60 gummies (30-60 servings). A subscription costs $71.20, saving you 20%.

Summary

FAB CBD’s PM Chews combine several calming ingredients that may reduce anxiety attacks and general anxiety triggered by poor sleep or nighttime.

>>Check the best deals for PM Chews here at FAB CBD

Cornbread Hemp - Top Organic CBD Gummies

Pros

  • Organic ingredients

  • Choose between three flavors

  • 20mg, 25mg, and 50mg CBD doses available

Cons

  • Contains THC

Who is Cornbread Hemp CBD Gummies Best For?

Cornbread Hemp’s organic CBD gummies are best for you if you want an organic CBD product or to choose between several doses.

Who Should Avoid Cornbread Hemp CBD Gummies?

Avoid Cornbread Hemp’s full-spectrum gummies if you cannot have any amount of THC. Even just 1mg can make you test positive for cannabis.

Cornbread Hemp CBD Gummies Ranking - 4.8/5

Effectiveness - 4.9/5

We love Cornbread Hemp’s gummies for your ability to choose your CBD potency. People who are more sensitive to CBD can choose 2 0mg or 25 mg jars. If you need a higher dose, you can choose the 50mg option, the same as some volunteers in the case series on CBD and anxiety [1].

Flavor - 4.9/5

Choose between berry, peach, and watermelon organic fruit flavors.

Customer Reviews - 4.8/5

Customer reviews include “I definitely notice a difference. I feel calmer in my day to day activities. Great product! Will definitely purchase again.”

Price - 4.8/5

Subscriptions for the 20mg CBD potency cost $31.99, while the 25mg and 50mg strengths cost $39.99 and $59.99, respectively. One-time purchases for these cost $39.99, $49.99, and $74.99.

Summary

Cornbread Hemp’s CBD gummies offer versatility in both flavor and dosage. Better yet, they’re organic.

>>Buy CBD gummies from Cornbread Hemp at the best prices here

Batch CBD Nighttime CBD + CBN Gummies - Great for Early Risers

Pros

  • They may promote healthy sleep without melatonin

  • Organic syrups and other ingredients

  • Original and Extra Strength versions

Cons

  • Passionflower may interact with other sedative medications.

Who is Batch CBD Nighttime CBD + CBN Gummies Best For?

Batch CBD’s CBD + CBN gummies may ease anxiety for people whose symptoms are worse with poor sleep. Their lack of melatonin makes them especially suitable if you don’t want to feel groggy in the morning.

Who Should Avoid Batch CBD Nighttime CBD + CBN Gummies?

Batch CBD’s nighttime gummies contain passionflower, which may be unsafe alongside other medications with strong sedative effects.

Batch CBD Nighttime CBD + CBN Gummies Ranking - 4.8/5

Effectiveness - 4.8/5

Batch CBD combines CBD with CBN, one of the minor cannabinoids with a potential sedative effect. A study on a CBN dose of 20mg, similar to that in Batch CBD gummies, found that it significantly reduced sleep disturbance and nighttime awakenings. It may have also improved sleep quality overall, too [5].

Although the above study didn’t show much benefit from adding CBD, it only ran for a week. The large case series on CBD for sleep and anxiety involved long-term use and showed stronger results, partly because some people took up to 75mg. Batch CBD offers both an Original dose of 25mg of CBD, plus an Extra Strength version of 50mg.

Flavor - 4.8/5

Batch CBD’s Nighttime Gummies come in a sweet natural raspberry flavor.

Customer Reviews - 4.8/5

Customer reviews often describe significant relief, including this comment: “The flavor isn’t bad and they help me sleep. I don’t sleep well sometimes even with sleep medication but by taking two, I was able to sleep. I have only taken two.”

Price - 4.8/5

While the Original strength gummies cost $59.99 for a one-time purchase, the Extra Strength version costs $74.99. Their subscriptions cost $47.99 and $59.99, respectively.

Summary

Batch CBD’s use of CBD and CBN means you can enjoy a refreshing night’s sleep without the “hangover” seen in melatonin use.

>>Check the best deals here for Batch CBD’s Nighttime CBD + CBN Gummies

Plus CBD Calm Gummies - Top CBD Gummies for Beginners

Pros

  • Whole, natural hemp extract

  • Added L-theanine and 5-HTP for extra stress relief

  • Organic, natural sugars and flavors

Cons

  • Contains less CBD than other gummies

Who is Plus CBD Calm Gummies Best For?

With a lower dose per CBD gummy, this is a full-spectrum CBD option appropriate for beginners or those more sensitive to CBD.

Who Should Avoid Plus CBD Calm Gummies?

Avoid Plus CBD’s Calm Gummies if you take antidepressants. 5-HTP, a precursor to serotonin, may have an additive effect with anything else that boosts serotonin.

Plus CBD Calm Gummies Ranking - 4.8/5

Effectiveness - 4.8/5

Calm Gummies pack a punch with the power of CBD, 5-HTP, and L-theanine combined. 5-HTP may not only help relieve depression, but has also been shown to reduce the severity of anxiety. This is because serotonin has both uplifting and calming effects [6].

Flavor - 4.9/5

Calm Gummies are made with a delicious strawberry lemonade flavor.

Customer Reviews - 4.8/5

Reviews for CBD Calm gummies include: “Be Calm is my mantra and I love this product! I have been known to get anxious when I am at work but one of these gummies per day produces a Zen effect on my moods and I am a firm believer in the benefits of CBD. Zentastic!”

Price - 4.8/5

A jar of 60 gummies costs $55.99, or you can save 25% with a subscription for $41.99.

Summary

Plus CBD’s lower CBD dose makes it suitable for beginners. The addition of 5-HTP and L-theanine, however, mean you likely won’t miss out on results.

>>Check the best deals for Plus CBD Calm Gummies here

Zatural CBD Gummies - Most Transparent

Pros

  • Test results available for terpenes, heavy metals, and potency

  • Choose between 30, 60, and 90-gummy jars

  • Provides a dosage guide

Cons

  • May contain THC

Who is Zatural CBD Best For?

If you need all of the details, Zatural provides them with test results for potency, terpenes, heavy metals, pesticides, solvents, and microbes. They also have three size choices and a dosage guide.

Who Should Avoid Zatural CBD?

These gummies contain small amounts of THC, so avoid them if you undergo drug testing.

Zatural CBD Ranking - 4.7/5

Effectiveness - 4.8/5

Zatural’s commitment to transparency means you can see levels of terpenes in their CBD products, including in these gummies.

The main terpene present is alpha-bisabolol. Lab studies show it is a powerful anti-inflammatory when using mice with dermatitis as an example [7]. Not only can anxiety increase inflammation, but inflammation can contribute to anxiety, too [8].

Flavor - 4.6/5

Zatural’s CBD gummies come in a natural berry flavor, which is not specified.

Customer Reviews - 4.7/5

Customers describe Zatural CBD products as effective for issues such as sleep and pain relief:

“Age has created issues in several of my muscles and joints…Through medical suggestion I found CBDs, through the internet I found Zatural. I have used several of their products through the years, gummies, Hot Cream, and sleep aides and found all to be premium products!”

Price - 4.7/5

While the 30-gummy jar costs $44.99, the 60-gummy jar is $74.99 and the 90-gummy jar costs $99.99.

Summary

Zatural leaves no stone unturned with its comprehensive third-party testing, which reveals a lesser-known but potent terpene.

>>Check the best deals for Zatural’s CBD gummies here

CBDfx CBD Gummies for Sleep with Melatonin - Best for High Doses

Pros

  • Each CBD dose can be up to 100mg

  • Added melatonin for sleep

  • Chamomile, passionflower, and lemon balm may have added benefits

  • THC-free formulation

Cons

  • Melatonin can leave you feeling groggy

Who is CBDfx CBD Gummies for Sleep with Melatonin Best For?

We recommend CBDfx’s gummies if you need a high dose of CBD. Thanks to their value for money and stronger potency, you can reach up to 100mg with a recommended dose.

Who Should Avoid CBDfx CBD Gummies for Sleep with Melatonin?

Avoid these gummies if you need something for daytime use, as melatonin is a sleep hormone.

CBDfx CBD Gummies for Sleep with Melatonin Ranking - 4.7/5

Effectiveness - 4.8/5

Not only can doses of up to 100mg of CBD be more effective, but the added herbal remedies can help, too. Passionflower, chamomile, and lemon balm are all shown to increase GABA, a major calming neurotransmitter [9].

Flavor - 4.5/5

These gummies have a mystery flavor, as it is not specified.

Customer Reviews - 4.7/5

Reviewer’s comments include: “I take one of each at bedtime..I fall asleep quickly (equal to oils), within minutes. I sleep with a mask and CPAP machine for 6 ½ - 7 hours and my obstructive incidents are lower than they’ve been for a long time.”

Price - 4.7/5

The 3,000mg jar (50mg per gummy) costs $84.99 for a one-time purchase and $63.74 for a subscription. The 1,500mg jar’s costs are $54.99 and $41.24.

Summary

For high doses at affordable prices, think CBDfx’s CBD gummies.

>>Check the best deals for CBDfx CBD Gummies for Sleep with Melatonin

Green Roads Sleepy Z’s Bedtime CBD Gummies - Convenient Packaging

Pros

  • Purchase in pouches of two gummies each

  • Combines CBD with CBN

  • Broad-spectrum CBD gummies

Cons

  • May be too sedating; contains melatonin

Who is Green Roads Sleepy Z’s Bedtime CBD Gummies Best For?

We recommend these gummies if you need something to wind down at the end of the day.

Who Should Avoid Green Roads Sleepy Z’s Bedtime CBD Gummies?

Sleepy Z’s Bedtime Gummies contain melatonin, so they are not recommended for daytime use.

Green Roads Sleepy Z’s Bedtime CBD Gummies Ranking - 4.6/5

Effectiveness - 4.8/5

With 25mg of CBD and 5mg of CBN, these gummies may help relieve anxiety and insomnia at night. You can double them up for stronger results if you need it, too.

Flavor - 4.8/5

These gummies come in a sweet natural blackberry flavor.

Customer Reviews - 4.7/5

Customer reviews include “Finally I found something to not only help me to drift off to sleep but stay asleep. I haven’t felt this good in ages.”

Price - 4.4/5

The price for a whole jar is unknown, but a pouch of two gummies appears to be $4.99.

Summary

Green Roads offers convenience with each dose (or two doses) individually wrapped in pouches.

>>Check the best deals for Green Roads’ Sleepy Z’s Bedtime Gummies here

Medterra Deep Sleep Gummies - Most Affordable

Pros

  • $1 per dose or less with a subscription

  • 3mg of added melatonin

  • Vegan-friendly

  • Other cannabinoids for the entourage effect

Cons

  • Contains THC

  • Melatonin may be too sedating

Who is Medterra Deep Sleep Gummies Best For?

Last but not least, Medterra’s Deep Sleep Gummies can be a great option for people on a budget.

Who Should Avoid Medterra Deep Sleep Gummies?

As these gummies contain THC and melatonin, they are unsuitable for people undergoing drug testing or those wanting gummies for daytime use.

Medterra Deep Sleep Gummies Ranking - 4.6/5

Effectiveness - 4.8/5

With 25mg of CBD and small amounts of THC and minor cannabinoids, Medterra’s gummies match those used in longer-term research [1]. Melatonin, the sleep hormone, likely provides you with added benefits.

Flavor - 4.5/5

Medterra’s gummies come in natural, unspecified mixed berry flavors.

Customer Reviews - 4.7/5

Reviews include: “I got these for my wife who has trouble sleeping. She thinks they are too strong so she cuts them in half. I don’t know what the recommended dosage is but she seems to get by with half a gummy each night.”

Price - 4.9/5

Subscriptions for 20-gummy, 40-gummy, and 60-gummy jars cost $27.99, $41.99, and $53.19, respectively. As one-time purchases, their prices are $39.99, $59.99, and $74.99.

Summary

Medterra gives you affordable yet effective CBD gummies that may relieve anxiety and improve sleep.

>>Check the best deals for Medterra’s Deep Sleep Gummies here

What Is CBD for Anxiety?

Cannabidiol (CBD) is a major cannabinoid in cannabis and the hemp plant. It does not have psychoactive effects like THC, but may relieve anxiety symptoms. As of 2018, the federal Farm Bill made CBD legal, paving the way for the cannabinoid as a potential treatment nationwide.

Benefits And Effects of CBD Gummies for Anxiety

CBD products such as gummies may help relieve symptoms of both physical and mental health conditions.

Boosting Vitality

By reducing stress, anxiety and inflammation, while improving sleep, CBD may increase your energy levels.

Improving Sleep Quality

CBD can significantly improve sleep. A case series on CBD for anxiety and insomnia found that sleep scores improved from 13.08 to 9.33 within three months [1].

Relieving Joint Discomfort

Joint pain can be caused by injury, aging, or a chronic disease. Thankfully, a large survey found that CBD reduced joint pain by 44% overall, with two-thirds describing improved physical function [10].

Promotion Of Gastrointestinal Well-Being

By soothing inflammation, CBD could improve gastrointestinal health in people with conditions such as Crohn’s disease. One paper showed a reduction in disease activity from 282 to 166 with CBD use [11].

Relief From PTSD Symptoms

The anti-inflammatory properties of CBD may also relieve PTSD. A lab study found that the combination of reducing inflammation and increasing the body’s own cannabinoids significantly reduced symptoms [12].

Treating Anxiety And Beyond

By acting on your endocannabinoid receptors and serotonin pathways to produce a calming effect, CBD may soothe anxiety. One case series found that anxiety scores fell from 23.87 to 16.36, for example [1].

Reducing The Risk Of Seizures

The calming effects of CBD on the brain are famous for their potential to relieve seizures. One study showed that seizures per month dropped from 12.4 to 5.9 with CBD oil. This study tested CBD on children with Dravet syndrome, a notorious, dangerous form of epilepsy [13].

>>Check the best prices for FOCL Feel Good’s CBD + THC Gummies here

How to Choose a CBD Oil for Stress

Ingredients, customer reviews, and third-party testing are critical factors when choosing CBD products for stress and anxiety.

Customer Reviews

Customer reviews from verified buyers and sites that the company cannot control show you the real experience of using the product. They provide extra information on benefits, side effects, and customer service.

Third-Party Lab Tests

Third-party testing is essential to learn whether or not the CBD oil or gummies contain what the label claims. The third-party companies do not have a major financial interest in any particular brand, so their test results are transparent. They also rule out the presence of contaminants.

Ingredients

Many CBD gummies contain additional ingredients that can improve brain health and soothe anxiety. Full- and broad-spectrum CBD gummies often have terpenes from certain strains, which may lift mood or have a relaxing effect.

Strength of CBD Oil

Next, check the strength of each CBD dose. You should have at least 25mg of CBD a day to relieve anxiety with regular use [1].

Legality

The legal amount of THC varies by state. On the other hand, CBD is federally legal thanks to the 2018 Farm Bill.

Flavored vs Unflavored

Depending on your preferences, you may want an unflavored CBD oil or sweet, candy-like gummies. Otherwise, you can expect a slight hemp flavor.

Check the THC Content

The right THC content for you depends on your tolerance level and whether you’ll run into any legal trouble. Avoid all THC-containing products if you undergo drug testing or expect to in the near future.

Safety and Side Effects of CBD for Anxiety

Using CBD for anxiety itself has minimal to no side effects. Higher doses can cause diarrhea, sleepiness, fatigue, and vomiting [13] but these are less relevant to the products reviewed here.

However, full-spectrum CBD products can cause issues because of their THC content. It’s best to choose a THC-free alternative if you cannot take any.

Recommended Dosage

The recommended dose depends on your needs, such as whether you need it for general stress relief or an issue such as panic attacks.

Research we found used CBD at doses of 25-75mg. High doses are best for acute use or as a loading dose. For example, papers on CBD products for short-term anxiety relief use doses of 300-600mg.

>>Check the best prices for FOCL Feel Good’s CBD + THC Gummies here

Potential Side Effects and Precautions

CBD gummies have minimal side effects. However, you can still fail a drug test if they contain THC. We recommend using broad-spectrum gummies or those with CBD isolates if you undergo drug testing.

Combining CBD Gummies With Other Anxiety Management Techniques

CBD can make other anxiety management techniques that retrain your brain more effective by taking the edge off of your symptoms.

We do not recommend that people with treatment-resistant anxiety disorders rely on any one intervention alone. It’s best to use a combination of therapies for long-term relief of problems such as panic attacks.

How We Picked the Best CBD Gummies for Anxiety

When we chose the best CBD gummies, we had several criteria in mind:

  • CBD potency: The potency had to be strong enough for an effective everyday dose. It also affects how many CBD gummies you may need for an initial “loading” or acute dose.

  • Additional ingredients: Some CBD products have supporting ingredients such as ashwagandha, L-tyrosine, or GABA to enhance stress management, focus, or sleep.

  • Value for money: Anxiety disorders can be long-term or be triggered during certain situations that you may be unable to avoid.

  • Third-party testing: This ensures that the dose per CBD gummy is what the label claims.

  • Customer reviews: We had to see that a large number of verified buyers gave positive feedback on efficacy, taste, and value.

>>Check the best prices for FOCL Feel Good’s CBD + THC Gummies here

FAQs

Here are some questions you may have when choosing CBD gummies for anxiety.

What Edibles Are Good for Anxiety?

We recommend CBD gummies. They are convenient and discreet, suitable for generalized social anxiety disorder because you can take them anytime, anywhere.

Is It Safe To Take CBD for Anxiety?

Yes. CBD oil and other products such as gummies have minimal to no side effects and do not cause paranoia like THC can.

What Is the Best CBD to Take for Anxiety?

If you’re interested in taking CBD gummies to relieve anxiety, FOCL Feel Good gummies are our favorite. Their dose of CBD is safe enough for self-treatment in the vast majority of people and added L-tyrosine may support mood and focus.

What if You Don’t Feel Anything From CBD Gummies?

If you do not see results, increase the dosage to up to 50-75mg or seek professional medical advice.

Which Method of CBD Is Best for Anxiety?

The best way of taking CBD depends on the individual. However, edibles such as gummies may last longer.

Is CBD Better Than Antidepressants?

Everyone is different, but many people notice better results with CBD for depression because of its lower side effect profile and ability to work with the body’s natural processes.

Final Thoughts

CBD products such as gummies are increasingly popular for issues such as high stress levels and panic attacks. However, you need to find the right ones.

The best CBD gummies for anxiety contain full- or broad-spectrum CBD, taste good, and are affordable. They may include additional ingredients such as tyrosine or herbal remedies to boost their effects.

Overall, our favorite gummy is FOCL Feel Good CBD + THC Gummies. They keep their full-spectrum CBD gummies safe and likely effective with a dose shown to calm anxiety when used over a long period.

References

  1. Shannon, Scott et al. “Cannabidiol in Anxiety and Sleep: A Large Case Series.” The Permanente journal vol. 23 (2019): 18-041. doi:10.7812/TPP/18-041

  2. Jongkees, Bryant J et al. “Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.” Journal of psychiatric research vol. 70 (2015): 50-7. doi:10.1016/j.jpsychires.2015.08.014

  3. Berthold, Erin C et al. “Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products.” European journal of drug metabolism and pharmacokinetics vol. 48,4 (2023): 427-435. doi:10.1007/s13318-023-00839-3

  4. Speers, Alex B et al. “Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia.” Current neuropharmacology vol. 19,9 (2021): 1468-1495. doi:10.2174/1570159X19666210712151556

  5. Bonn-Miller, Marcel O et al. “A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality.” Experimental and clinical psychopharmacology vol. 32,3 (2024): 277-284. doi:10.1037/pha0000682

  6. Maffei, Massimo E. “5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology.” International journal of molecular sciences vol. 22,1 181. 26 Dec. 2020, doi:10.3390/ijms22010181

  7. Karami, Homa et al. “Development of a hydrogel containing bisabolol-loaded nanocapsules for the treatment of atopic dermatitis in a Balb/c mice model.” International journal of pharmaceutics vol. 656 (2024): 124029. doi:10.1016/j.ijpharm.2024.124029

  8. Salim, Samina et al. “Inflammation in anxiety.” Advances in protein chemistry and structural biology vol. 88 (2012): 1-25. doi:10.1016/B978-0-12-398314-5.00001-5

  9. Savage, Karen et al. “GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.” Phytotherapy research : PTR vol. 32,1 (2018): 3-18. doi:10.1002/ptr.5940

  10. Frane, Nicholas et al. “Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study.” Journal of cannabis research vol. 4,1 47. 24 Aug. 2022, doi:10.1186/s42238-022-00154-9

  11. Naftali, Timna et al. “Oral CBD-rich Cannabis Induces Clinical but Not Endoscopic Response in Patients with Crohn’s Disease, a Randomised Controlled Trial.” Journal of Crohn’s & colitis vol. 15,11 (2021): 1799-1806. doi:10.1093/ecco-jcc/jjab069

  12. Xie, Guanbo et al. “Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice.” Brain, behavior, and immunity vol. 119 (2024): 945-964. doi:10.1016/j.bbi.2024.05.016

  13. Devinsky, Orrin et al. “Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome.” The New England journal of medicine vol. 376,21 (2017): 2011-2020. doi:10.1056/NEJMoa1611618

The information regarding cannabis, cannabis-related, THC and CBD products is for informational and educational purposes only, not substituting professional medical advice or treatment. We do not promote or endorse the use, sale, or distribution of cannabis where it's not legally permitted. The legality of cannabis varies by state and jurisdiction, and we urge users to comply with all federal, state, and local laws concerning its use and sale. We encourage users to consult with healthcare professionals. We might earn a commission if you make a purchase through one of the links. McClatchy's Commerce Content team, which is independent from our newsroom, oversees this content.